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\r\n \u52a0\u9f62\u306b\u4f34\u3044\u3001\u8ee2\u5012\u306a\u3069\u306b\u3088\u308b\u7b4b\u8089\u306e\u640d\u50b7\u304c\u6cbb\u308a\u306b\u304f\u304f\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6d3b\u52d5\u91cf\u304c\u6e1b\u3063\u3066\u3001\u7b4b\u8089\u91cf\u304c\u6e1b\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u82e5\u9f62\u6642\u3068\u9aa8\u683c\u7b4b\u306e\u6027\u8cea\uff08\uff1d\u4f53\u8cea\uff09\u304c\u5909\u308f\u308b\u305f\u3081\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u52a0\u9f62\u306b\u3088\u3063\u3066\u3082\u82e5\u9f62\u6642\u3068\u6bd4\u3079\u3066\u907a\u4f1d\u5b50\u914d\u5217\u81ea\u4f53\u306f\u5909\u308f\u3089\u306a\u3044\u305f\u3081\u3001\u907a\u4f1d\u5b50\u914d\u5217\u4ee5\u5916\u306e\u4f55\u3089\u304b\u306e\u5909\u5316\u304c\u3042\u308b\u3068\u4e88\u60f3\u3055\u308c\u307e\u3059\u3002\u907a\u4f1d\u5b50\u306e\u5909\u5316\u306b\u300cDNA\u30e1\u30c1\u30eb\u5316\u300d\u304c\u77e5\u3089\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u9ad8\u9f62\u8005\u306e\u9aa8\u683c\u7b4b\u306e\u6027\u8cea\uff08\uff1d\u4f53\u8cea\uff09\u304c\u3001\u82e5\u9f62\u671f\u304b\u3089\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u3068\u3044\u3046\u65b0\u305f\u306a\u8996\u70b9\u304b\u3089\u3001\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u30e2\u30c7\u30eb\u3068\u3057DNA\u30e1\u30c1\u30eb\u5316\u5909\u5316\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u9ad8\u9f62\u8005\u3067\u306f\u82e5\u9f62\u8005\u3068\u6bd4\u3079\u3066\u3001\u7b4b\u8089\u306e\u56de\u5fa9\u306b\u91cd\u8981\u306a\u7b4b\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u306eDNA\u30e1\u30c1\u30eb\u5316\u5909\u5316\u304c\u8d77\u3053\u308a\u3001\u7b4b\u640d\u50b7\u306e\u56de\u5fa9\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u65b0\u305f\u306a\u5b9f\u9a13\u30c7\u30fc\u30bf\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\r\n
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\r\n \u8ee2\u5012\u304b\u3089\u306e\u56de\u5fa9\u4e0d\u5168\u306b\u3088\u308a\u5bdd\u305f\u304d\u308a\u306b\u306a\u308b\u3068\u3001\u4ecb\u8b77\u304c\u5fc5\u8981\u3068\u306a\u308a\u3001\u307e\u305f\u8a8d\u77e5\u75c7\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u672c\u7814\u7a76\u3092\u624b\u304c\u304b\u308a\u3068\u3057\u3066\u3001\u5bdd\u305f\u304d\u308a\u3092\u4e88\u9632\u30fb\u6539\u5584\u3057\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u533b\u85ac\u54c1\u3084\u6a5f\u80fd\u6027\u98df\u54c1\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\r\n
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\r\n \u672c\u7814\u7a76\u3067\u306f\u3001\u8001\u9f62\u30de\u30a6\u30b9\u306e\u9aa8\u683c\u7b4b\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8001\u5316\u306b\u3088\u308aDNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u3067\u3042\u308bDnmt3a\u304c\u767a\u73fe\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u6539\u5909\u306b\u3088\u308a\u82e5\u9f62\u30de\u30a6\u30b9\u306e\u9aa8\u683c\u7b4b\u3067Dnmt3a\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3001\u7b4b\u640d\u50b7\u5f8c\u306e\u7b4b\u518d\u751f\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002DNA\u30e1\u30c1\u30eb\u5316\u5909\u5316\u3092\u4ecb\u3057\u3066GDF5\uff08Growth Differentiation Factor 5\uff09\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u3001\u7b4b\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u306e\u5f62\u6210\u30fb\u7b4b\u518d\u751f\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002
\r\n \u3053\u306e\u3088\u3046\u306b\u672c\u7814\u7a76\u3067\u306f\u3001\u9ad8\u9f62\u8005\u306e\u7b4b\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308b\u7406\u7531\u306e\u4e00\u7aef\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\r\n
\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb
\r\n Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration FASEB Journal. 2018.<\/p>","protected":false},"excerpt":{"rendered":"
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