{"id":2918,"date":"2026-04-16T08:54:10","date_gmt":"2026-04-15T23:54:10","guid":{"rendered":"https:\/\/kpu-als.jp\/w\/?p=2918"},"modified":"2026-04-16T08:54:10","modified_gmt":"2026-04-15T23:54:10","slug":"molecular-nutrition_pnas","status":"publish","type":"post","link":"https:\/\/kpu-als.jp\/w\/2026\/04\/molecular-nutrition_pnas\/","title":{"rendered":"\u5206\u5b50\u6804\u990a\u5b66\u7814\u7a76\u5ba4\u306e\u7814\u7a76\u6210\u679c\u304c\u56fd\u969b\u5b66\u8853\u8a8c\u300cPNAS\u300d\uff08\u7c73\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<h4><b><span data-contrast=\"auto\">\u6804\u990a\u6b20\u4e4f\u6642\uff08\u98e2\u9913\u6642\uff09\u306e\u8102\u80aa\u809d\u306e\u767a\u75c7\u306b\u9aa8\u683c\u7b4b\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\uff01<\/span><\/b><\/h4>\r\n<pre><span style=\"font-size: 12pt;\"><b>\u3000\u9aa8\u683c\u7b4b\u306e<\/b><b>FoxO<\/b><b>\u907a\u4f1d\u5b50\u304c\u8102\u80aa\u809d\u3092\u8abf\u7bc0\u3059\u308b\uff01<\/b><\/span><\/pre>\r\n<p><span data-contrast=\"auto\"><br \/>\r\n\u4eac\u90fd\u5e9c\u7acb\u5927\u5b66 \u8fb2\u5b66\u98df\u79d1\u5b66\u90e8 \u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u79d1 \u5206\u5b50\u6804\u990a\u5b66\u7814\u7a76\u5ba4\u306e\u5927\u85ea\u8475\u8b1b\u5e2b\u3068\u4e80\u4e95\u5eb7\u5bcc\u6559\u6388\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7<\/span><span data-contrast=\"auto\">\u306f\u3001<\/span><span style=\"text-decoration: underline;\"><strong>\u6804\u990a\u6b20\u4e4f\u6642\uff08\u98e2\u9913\u6642\uff09\u306e\u8102\u80aa\u809d\u306e\u767a\u75c7\u306b\u9aa8\u683c\u7b4b\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057<\/strong><\/span><span data-contrast=\"auto\">\u3001\u3053\u306e\u5185\u5bb9\u304c\u56fd\u969b\u5b66\u8853\u8a8c\u300c<\/span><b><span data-contrast=\"auto\">PNAS<\/span><\/b><b><span data-contrast=\"auto\">\uff08<\/span><\/b><b><span data-contrast=\"auto\">\u7c73\u56fd\u79d1\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u7d00\u8981<\/span><\/b><b><span data-contrast=\"auto\">\uff09<\/span><\/b><span data-contrast=\"auto\">\u300d\u306b<\/span><span data-contrast=\"auto\">2026<\/span><span data-contrast=\"auto\">\u5e74<\/span><span data-contrast=\"auto\">4<\/span><span data-contrast=\"auto\">\u6708<\/span><span data-contrast=\"auto\">8<\/span><span data-contrast=\"auto\">\u65e5\u4ed8\u3051\u306b\u3066\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/span><span data-ccp-props=\"{&quot;134245417&quot;:false,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:210,&quot;335559797&quot;:100}\">\u00a0<br \/>\r\n<\/span><\/p>\r\n<p><span data-contrast=\"auto\">\u73fe\u5728\u3001\u4e16\u754c\u306e\u6210\u4eba\u306e\u7d04<\/span><span data-contrast=\"auto\">3<\/span><span data-contrast=\"auto\">\u4eba\u306b\uff11\u4eba\u304c\u3001\u809d\u81d3\u306b\u8102\u80aa\u304c\u84c4\u7a4d\u3059\u308b\u300c\u8102\u80aa\u809d\u300d\u3092\u60a3\u3063\u3066\u3044\u307e\u3059\u3002\u8102\u80aa\u809d\u304c\u9032\u884c\u3059\u308b\u3068\u3001\u8102\u80aa\u809d\u708e\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u809d\u81d3\u306e\u7dda\u7dad\u5316\u3092\u7d4c\u3066\u3001\u6b21\u7b2c\u306b\u809d\u786c\u5909\u3084\u809d\u304c\u3093\u306b\u81f3\u308a\u307e\u3059\u3002<\/span><\/p>\r\n<p><span data-contrast=\"auto\">\u305d\u306e\u305f\u3081\u3001\u8102\u80aa\u809d\u306e\u767a\u75c7\u6a5f\u5e8f\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u91cd\u8981\u306a\u5b66\u8853\u7684\u8ab2\u984c\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u8102\u80aa\u809d\u306e\u75c5\u614b\u767a\u75c7\u306b\u306f\u3001\u80a5\u6e80\u3084\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u306e\u904e\u5270\u6442\u53d6\u306a\u3069\u306e\u904e\u6804\u990a\u304c\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u3067\u306f\u3001\u904e\u6804\u990a\u3068\u306f\u5bfe\u7167\u7684\u306a\u904e\u5ea6\u306e\u6804\u990a\u5931\u8abf\u3084\u305d\u308c\u306b\u4f34\u3046\u4f53\u91cd\u6e1b\u5c11\u304c\u3001\u8102\u80aa\u809d\u3092\u60aa\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\r\n<p><span data-contrast=\"auto\">\u307e\u305f\u3001\u82e5\u3044\u5973\u6027\u306b\u591a\u3044\u6975\u7aef\u306a\u30c0\u30a4\u30a8\u30c3\u30c8\u306b\u3088\u3063\u3066\u3082\u8102\u80aa\u809d\u304c\u8d77\u304d\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u3046\u3057\u305f\u8102\u80aa\u809d\u306e\u767a\u75c7\u306b\u3001\u809d\u81d3\u4ee5\u5916\u306e\u81d3\u5668\u304c\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304b\u306f\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\r\n<\/span><span data-ccp-props=\"{&quot;134245417&quot;:false,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:210,&quot;335559797&quot;:100}\">\u00a0<br \/>\r\n<br \/>\r\n<\/span><span data-contrast=\"auto\">\u4eca\u56de\u3001\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5b9f\u9a13\u304b\u3089\u4ee5\u4e0b\u306e\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\r\n<br \/>\r\n<\/span><\/p>\r\n<ol>\r\n\t<li><strong>\u6804\u990a\u6b20\u4e4f\u6642\uff08\u98e2\u9913\u6642\uff09\u306b\u306f\u9aa8\u683c\u7b4b\u5185\u3067FoxO\u3068\u547c\u3070\u308c\u308b\u907a\u4f1d\u5b50\u304c\u8102\u8cea\u4ee3\u8b1d\u3084\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u4ee3\u8b1d\u306a\u3069\u3092\u8abf\u7bc0\u3057\u3001\u809d\u81d3\u3078\u306e\u904e\u5270\u306a\u8102\u80aa\u84c4\u7a4d\u3092\u9632\u3050\u6a5f\u69cb\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/strong><\/li>\r\n\t<li><strong>\u809d\u81d3\u306b\u8102\u80aa\u304c\u84c4\u7a4d\u3057\u3084\u3059\u3044\u9ad8\u30b9\u30af\u30ed\u30fc\u30b9\u30fb\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u542b\u6709\u306e\u9ad8\u8102\u80aa\u98df\uff08\u30a6\u30a7\u30b9\u30bf\u30f3\u98df\uff09\u3092\u4e0e\u3048\u305f\u6642\u3001\u9aa8\u683c\u7b4b\u3067\u30d2\u30c8FoxO1\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u5897\u5f37\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u8102\u80aa\u809d\u708e\uff08MASH\uff1a\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff09\u69d8\u306e\u75c5\u614b\u767a\u75c7\u304c\u8d77\u304d\u306b\u304f\u3044\u3053\u3068<\/strong><span data-contrast=\"auto\"><strong>\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/strong><br \/>\r\n<br \/>\r\n<\/span><\/li>\r\n<\/ol>\r\n<p><span data-contrast=\"auto\">\u3053\u308c\u306b\u3088\u308a\u3001\u9aa8\u683c\u7b4b\u304c\u809d\u81d3\u306e\u75c5\u614b\u30fb\u751f\u7406\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3001\u8102\u80aa\u809d\u8abf\u7bc0\u306b\u304a\u3051\u308b\u8907\u96d1\u3067\u5de7\u5999\u306a\u81d3\u5668\u9593\u306e\u9023\u95a2\u6a5f\u69cb\u306e\u5b58\u5728\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\r\n<\/span><\/p>\r\n<p><span data-contrast=\"auto\">\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u3001\u98e2\u9913\u9069\u5fdc\u306b\u304a\u3051\u308b\u751f\u4f53\u6052\u5e38\u6027\u3092\u8abf\u7bc0\u3059\u308b\u9aa8\u683c\u7b4b<\/span><span data-contrast=\"auto\">FoxO<\/span><span data-contrast=\"auto\">\u907a\u4f1d\u5b50\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3082\u306e\u3067\u3059<\/span><span data-contrast=\"auto\">\uff08<strong>\u6982\u8981\u56f3<\/strong><\/span><span data-contrast=\"auto\">\uff09<\/span><span data-contrast=\"auto\">\u3002<\/span><span data-ccp-props=\"{&quot;134245417&quot;:false,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559731&quot;:210,&quot;335559797&quot;:100}\">\u00a0<\/span><\/p>\r\n<p>&nbsp;<\/p>\r\n<p style=\"text-align: center;\">\u3010\u6982\u8981\u56f3\u3011<\/p>\r\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone  wp-image-2938 aligncenter colorbox-2918\" src=\"https:\/\/kpu-als.jp\/w\/wp-content\/uploads\/2026\/04\/32df2e105438a7d07f2315a60a91390c-424x450.jpg\" alt=\"\" width=\"526\" height=\"558\" srcset=\"https:\/\/kpu-als.jp\/w\/wp-content\/uploads\/2026\/04\/32df2e105438a7d07f2315a60a91390c-424x450.jpg 424w, https:\/\/kpu-als.jp\/w\/wp-content\/uploads\/2026\/04\/32df2e105438a7d07f2315a60a91390c-754x800.jpg 754w, https:\/\/kpu-als.jp\/w\/wp-content\/uploads\/2026\/04\/32df2e105438a7d07f2315a60a91390c-1448x1536.jpg 1448w, https:\/\/kpu-als.jp\/w\/wp-content\/uploads\/2026\/04\/32df2e105438a7d07f2315a60a91390c-1930x2048.jpg 1930w\" sizes=\"(max-width: 526px) 100vw, 526px\" \/><\/p>\r\n<p><strong>\u2605\u8ad6\u6587\u60c5\u5831<\/strong><\/p>\r\n<table style=\"border-collapse: collapse; width: 100%;\">\r\n<tbody>\r\n<tr>\r\n<td style=\"width: 100%;\">\r\n<ol>\r\n\t<li>\u8ad6\u6587\u540d\uff1a<span lang=\"EN-US\">Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.<br \/>\r\n\uff08\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308bFoxO\u306e\u55aa\u5931\u306f\u3001\u7b4b\u8089\u4ee3\u8b1d\u306e\u4e71\u308c\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u98e2\u9913\u8a98\u767a\u6027\u306e\u8102\u80aa\u809d\u3092\u60aa\u5316\u3055\u305b\u308b\uff09<br \/>\r\n<\/span><\/li>\r\n\t<li>\u8457\u8005\uff1a \u00a0Mamoru Oyabu*, Manato Sakaue, Atsushi Kubo, Kiyoshi Yoshioka, Runa Kawaguchi, Haruki Yamamoto, Yuzuka Kinjo, Jungin Kwon, Hiroki Nishi, Daisuke Yamanaka, Tomoki Sato, Daiki Mori, Takahiro Eguchi, Naoki Ito, So-ichiro Fukada, Takayoshi Suganami, Shinji Miura, Yusuke Ono, Fumihiko Hakuno, Shin-ichiro Takahashi, Tsuyoshi Goto, Yasutomi Kamei*.\uff08*\u8cac\u4efb\u8457\u8005\uff09<br \/>\r\n\uff08\u5927\u85ea\u8475\u3001\u962a\u4e0a\u611b\u6597\u3001\u4e45\u4fdd\u7d14\u3001\u5409\u5ca1\u6f54\u5fd7\u3001\u5ddd\u53e3\u7559\u5948\u3001\u5c71\u672c\u9065\u5e0c\u3001\u91d1\u57ce\u67da\u82b1\u3001KwonJungi<span style=\"font-family: georgia, palatino, serif;\">n\u3001<\/span>\u897f\u5b8f\u8d77\u3001\u5c71\u4e2d\u5927\u4ecb\u3001\u4f50\u85e4\u53cb\u7d00\u3001\u68ee\u5927\u8f1d\u3001\u6c5f\u53e3\u8cb4\u5927\u3001\u4f0a\u85e4\u5c1a\u57fa\u3001\u6df1\u7530\u5b97\u4e00\u90ce\u3001\u83c5\u6ce2\u5b5d\u7965\u3001\u4e09\u6d66\u9032\u53f8\u3001\u5c0f\u91ce\u60a0\u4ecb\u3001\u4f2f\u91ce\u53f2\u5f66\u3001\u9ad8\u6a4b\u4f38\u4e00\u90ce\u3001\u5f8c\u85e4\u525b\u3001\u4e80\u4e95\u5eb7\u5bcc\uff09<\/li>\r\n\t<li>\u96d1\u8a8c\u540d\uff1a <strong><em>Proceedings of the National Academy of Sciences<\/em><\/strong>, 123 (15), e2600036123 (2026)<br \/>\r\n<br \/>\r\n<\/li>\r\n\t<li>DOI\uff1a<a style=\"font-family: inherit; font-size: inherit;\" href=\"https:\/\/doi.org\/10.1073\/pnas.2600036123\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1073\/pnas.2600036123<\/a><\/li>\r\n<\/ol>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<p><strong><br \/>\r\n\u2605\u5927\u5b66HP<\/strong><\/p>\r\n<p>\u3000\u3000\u3000\u3000<a href=\"https:\/\/www.kpu.ac.jp\/news\/kenkyuuseika20260415\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.kpu.ac.jp\/news\/kenkyuuseika20260415\/<\/a><\/p>\r\n<p><strong>\u2605\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/strong><\/p>\r\n<p>\u3000\u3000\u3000\u3000<a href=\"https:\/\/www.kpu.ac.jp\/media\/20260415Pressrelease.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/www.kpu.ac.jp\/media\/20260415Pressrelease.pdf<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u6804\u990a\u6b20\u4e4f\u6642\uff08\u98e2\u9913\u6642\uff09\u306e\u8102\u80aa\u809d\u306e\u767a\u75c7\u306b\u9aa8\u683c\u7b4b\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\uff01 \u3000\u9aa8\u683c\u7b4b\u306eFoxO\u907a\u4f1d\u5b50\u304c\u8102\u80aa\u809d\u3092\u8abf\u7bc0\u3059\u308b\uff01 \u4eac\u90fd\u5e9c\u7acb\u5927\u5b66 \u8fb2\u5b66\u98df\u79d1\u5b66\u90e8 \u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u79d1 \u5206\u5b50\u6804\u990a\u5b66\u7814\u7a76\u5ba4\u306e\u5927\u85ea\u8475\u8b1b\u5e2b\u3068\u4e80\u4e95\u5eb7\u5bcc\u6559\u6388\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u5171\u540c\u7814 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[6],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/posts\/2918"}],"collection":[{"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/comments?post=2918"}],"version-history":[{"count":85,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/posts\/2918\/revisions"}],"predecessor-version":[{"id":3229,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/posts\/2918\/revisions\/3229"}],"wp:attachment":[{"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/media?parent=2918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/categories?post=2918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kpu-als.jp\/w\/wp-json\/wp\/v2\/tags?post=2918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}